Programme

Programme

Programme

ECNM 2025 Annual Meeting - Programme

ECNM 2025 Annual Meeting - Programme

Day 1, Thursday 18

Day 1, Thursday 18

Day 1, Thursday 18

September 2025

September 2025

September 2025

12:00

Registration opens

12:00

Registration opens

12:00

Registration opens

12:30–12:40

Welcome

Deepti Radia & Clive Grattan

12:30–12:40

Welcome

Deepti Radia & Clive Grattan

12:30–12:40

Welcome

Deepti Radia & Clive Grattan

12:40–13:00

Welcome and introduction

• Status of the ECNM • Presentation of Researcher of the Year award

Peter Valent & Massimo Triggiani

12:40–13:00

Welcome and introduction

• Status of the ECNM • Presentation of Researcher of the Year award

Peter Valent & Massimo Triggiani

12:40–13:00

Welcome and introduction

• Status of the ECNM • Presentation of Researcher of the Year award

Peter Valent & Massimo Triggiani

13:00–13:40

Utility and application of KIT mutations and other molecular markers in mast cell neoplasms

Michel Arock

13:00–13:40

Utility and application of KIT mutations and other molecular markers in mast cell neoplasms

Michel Arock

13:00–13:40

Utility and application of KIT mutations and other molecular markers in mast cell neoplasms

Michel Arock

13:40–14:00

Afternoon coffee break

13:40–14:00

Afternoon coffee break

13:40–14:00

Afternoon coffee break

14:00–15:00

SESSION 1: Updates in pathology and classification

• Harmonisation of the EU/US, ICC and WHO classificationof mastocytosis • Application of ICC and WHO criteria by the pathologist • Histopathological and phenotypic changes of mast cellsduring TKI therapy • Rare cases and histopathological patterns in SM-AHN

Chaired by Wolfgang R Sperr & Karl Sotlar Peter Valent Karl Sotlar Tracy George Hans Peter Horny

14:00–15:00

SESSION 1: Updates in pathology and classification

• Harmonisation of the EU/US, ICC and WHO classificationof mastocytosis • Application of ICC and WHO criteria by the pathologist • Histopathological and phenotypic changes of mast cellsduring TKI therapy • Rare cases and histopathological patterns in SM-AHN

Chaired by Wolfgang R Sperr & Karl Sotlar Peter Valent Karl Sotlar Tracy George Hans Peter Horny

14:00–15:00

SESSION 1: Updates in pathology and classification

• Harmonisation of the EU/US, ICC and WHO classificationof mastocytosis • Application of ICC and WHO criteria by the pathologist • Histopathological and phenotypic changes of mast cellsduring TKI therapy • Rare cases and histopathological patterns in SM-AHN

Chaired by Wolfgang R Sperr & Karl Sotlar Peter Valent Karl Sotlar Tracy George Hans Peter Horny

15:00–15:30

Afternoon coffee break

15:00–15:30

Afternoon coffee break

15:00–15:30

Afternoon coffee break

15:30–16:45

SESSION 2: Updates in paediatric and adult dermatological presentations of mast cell disease

• Diagnosis and management of skin problems in paediatricmastocytosis • Quantification of skin disease in CM and SM during therapy • Therapy of cutaneous disease in pediatric CM • Phototherapy and photochemotherapy in CM and SM • Challenges and potential shortfalls in current classificationof cutaneous mastocytosis

Chaired by Magdalena Lange & Vito Sabato Melody Carter Karin Hartmann Magdalena Lange Valeria Brazzelli & Iván Álvarez-Twose

15:30–16:45

SESSION 2: Updates in paediatric and adult dermatological presentations of mast cell disease

• Diagnosis and management of skin problems in paediatricmastocytosis • Quantification of skin disease in CM and SM during therapy • Therapy of cutaneous disease in pediatric CM • Phototherapy and photochemotherapy in CM and SM • Challenges and potential shortfalls in current classificationof cutaneous mastocytosis

Chaired by Magdalena Lange & Vito Sabato Melody Carter Karin Hartmann Magdalena Lange Valeria Brazzelli & Iván Álvarez-Twose

15:30–16:45

SESSION 2: Updates in paediatric and adult dermatological presentations of mast cell disease

• Diagnosis and management of skin problems in paediatricmastocytosis • Quantification of skin disease in CM and SM during therapy • Therapy of cutaneous disease in pediatric CM • Phototherapy and photochemotherapy in CM and SM • Challenges and potential shortfalls in current classificationof cutaneous mastocytosis

Chaired by Magdalena Lange & Vito Sabato Melody Carter Karin Hartmann Magdalena Lange Valeria Brazzelli & Iván Álvarez-Twose

16:45–17:15

Afternoon coffee break

16:45–17:15

Afternoon coffee break

16:45–17:15

Afternoon coffee break

17:15–18:15

SESSION 3: Comorbidities in mastocytosis

• Bone health and disease management in patients with SM • Drug reactions and food intolerance in mastocytosis • Causes of death in patients with mastocytosis: Impactof comorbidities • IgE-dependent allergies in mastocytosis

Chaired by Knut Brockow & Massimo Triggiani Massimo Triggiani Mariana Castells Axel Rüfer Hanneke Oude Elberink

17:15–18:15

SESSION 3: Comorbidities in mastocytosis

• Bone health and disease management in patients with SM • Drug reactions and food intolerance in mastocytosis • Causes of death in patients with mastocytosis: Impactof comorbidities • IgE-dependent allergies in mastocytosis

Chaired by Knut Brockow & Massimo Triggiani Massimo Triggiani Mariana Castells Axel Rüfer Hanneke Oude Elberink

17:15–18:15

SESSION 3: Comorbidities in mastocytosis

• Bone health and disease management in patients with SM • Drug reactions and food intolerance in mastocytosis • Causes of death in patients with mastocytosis: Impactof comorbidities • IgE-dependent allergies in mastocytosis

Chaired by Knut Brockow & Massimo Triggiani Massimo Triggiani Mariana Castells Axel Rüfer Hanneke Oude Elberink

18:15–18:55

Keynote lecture 1:

Mast cells and basophils in allergo-oncology: Bridging allergy to cancer

Introduced by Clive Grattan Sophia Karagiannis

18:15–18:55

Keynote lecture 1:

Mast cells and basophils in allergo-oncology: Bridging allergy to cancer

Introduced by Clive Grattan Sophia Karagiannis

18:15–18:55

Keynote lecture 1:

Mast cells and basophils in allergo-oncology: Bridging allergy to cancer

Introduced by Clive Grattan Sophia Karagiannis

18:55–19:00

Summary of Day 1 and announcements

18:55–19:00

Summary of Day 1 and announcements

18:55–19:00

Summary of Day 1 and announcements

19:30–20:30

19:30–20:30

19:30–20:30

Networking reception

Networking reception

Networking reception

Join fellow attendees, faculty, and colleagues for an
evening of informal networking, accompanied by drinks and light refreshments, in the elegant
Riverview Lounge overlooking the River Thames.
This reception offers a valuable opportunity to continue discussions from the day in a relaxed setting
and to connect with peers from across the field.

Riverview Lounge, 12th Floor
Park Plaza London Riverbank Hotel, London

Kindly register for this reception
by 31 August via the following link: www.surveymonkey.com/r/XPPX26T

Join fellow attendees, faculty, and colleagues for an
evening of informal networking, accompanied by drinks and light refreshments, in the elegant
Riverview Lounge overlooking the River Thames.
This reception offers a valuable opportunity to continue discussions from the day in a relaxed setting
and to connect with peers from across the field.

Riverview Lounge, 12th Floor
Park Plaza London Riverbank Hotel, London

Kindly register for this reception
by 31 August via the following link: www.surveymonkey.com/r/XPPX26T

Join fellow attendees, faculty, and colleagues for an
evening of informal networking, accompanied by drinks and light refreshments, in the elegant
Riverview Lounge overlooking the River Thames.
This reception offers a valuable opportunity to continue discussions from the day in a relaxed setting
and to connect with peers from across the field.

Riverview Lounge, 12th Floor
Park Plaza London Riverbank Hotel, London

Kindly register for this reception
by 31 August via the following link: www.surveymonkey.com/r/XPPX26T

Day 2, Friday 19

Day 2, Friday 19

Day 2, Friday 19

September 2025

September 2025

September 2025

08:30

Welcome and registration

08:30

Welcome and registration

08:30

Welcome and registration

09:00–10:00

SESSION 4: ECNM Registry projects – part 1

• Overview of ECNM registry projects • Highlights in W1 through W8 projects • PR1: Analysis of various age groups • PR14: Body mass index in mastocytosis • PR18: Pure CM in adults

Chaired by Wolfgang R Sperr & Michel Arock Wolfgang R. Sperr Peter Valent Karin Hartmann Marek Niedoszytko Knut Brockow

09:00–10:00

SESSION 4: ECNM Registry projects – part 1

• Overview of ECNM registry projects • Highlights in W1 through W8 projects • PR1: Analysis of various age groups • PR14: Body mass index in mastocytosis • PR18: Pure CM in adults

Chaired by Wolfgang R Sperr & Michel Arock Wolfgang R. Sperr Peter Valent Karin Hartmann Marek Niedoszytko Knut Brockow

09:00–10:00

SESSION 4: ECNM Registry projects – part 1

• Overview of ECNM registry projects • Highlights in W1 through W8 projects • PR1: Analysis of various age groups • PR14: Body mass index in mastocytosis • PR18: Pure CM in adults

Chaired by Wolfgang R Sperr & Michel Arock Wolfgang R. Sperr Peter Valent Karin Hartmann Marek Niedoszytko Knut Brockow

10:00–10:20

Morning coffee break

10:00–10:20

Morning coffee break

10:00–10:20

Morning coffee break

10:20–11:00

SESSION 4: ECNM Registry projects – part 2

• PR19: AHN: Frequency of subtypes and prognosis • PR42: Clinical impact of KITD816V VAF in SM • PR45: Causes of death in non-advanced SM • Overview of new projects and EU grant application

Chaired by Wolfgang R Sperr & Michel Arock Olivier Hermine Frank Siebenhaar Axel Rüfer & Theo Gülen Peter Valent

10:20–11:00

SESSION 4: ECNM Registry projects – part 2

• PR19: AHN: Frequency of subtypes and prognosis • PR42: Clinical impact of KITD816V VAF in SM • PR45: Causes of death in non-advanced SM • Overview of new projects and EU grant application

Chaired by Wolfgang R Sperr & Michel Arock Olivier Hermine Frank Siebenhaar Axel Rüfer & Theo Gülen Peter Valent

10:20–11:00

SESSION 4: ECNM Registry projects – part 2

• PR19: AHN: Frequency of subtypes and prognosis • PR42: Clinical impact of KITD816V VAF in SM • PR45: Causes of death in non-advanced SM • Overview of new projects and EU grant application

Chaired by Wolfgang R Sperr & Michel Arock Olivier Hermine Frank Siebenhaar Axel Rüfer & Theo Gülen Peter Valent

11:00–11:15

Morning coffee break

11:00–11:15

Morning coffee break

11:00–11:15

Morning coffee break

11:15–12:00

SESSION SATELLITE MEETING – CLINICAL SCENARIOS

11:15–12:00

SESSION SATELLITE MEETING – CLINICAL SCENARIOS

11:15–12:00

SESSION SATELLITE MEETING – CLINICAL SCENARIOS

12:50–13:00

Group photo

12:50–13:00

Group photo

12:50–13:00

Group photo

13:00–13:45

Keynote lecture 2:

Molecular studies in mastocytosis and AHN, and use of AI tools

Introduced by Peter Valent Gregor Hörmann

13:00–13:45

Keynote lecture 2:

Molecular studies in mastocytosis and AHN, and use of AI tools

Introduced by Peter Valent Gregor Hörmann

13:00–13:45

Keynote lecture 2:

Molecular studies in mastocytosis and AHN, and use of AI tools

Introduced by Peter Valent Gregor Hörmann

13:45–15:00

SESSION 5: Diagnostic challenges in mastocytosis

• Lab features and flow cytometry correlates with clinicalphenotypes • I think I have the mast cell • HαT and implications in clinical practice • Early phases and pre-phases of mast cell neoplasms • Classification of pre-SM conditions and developmentof prevention strategies

Chaired by Iván Álvarez-Twose & Karin Hartmann Alberto Orfao Clive Grattan Jonathan Lyons Olivier Hermine Peter Valent

13:45–15:00

SESSION 5: Diagnostic challenges in mastocytosis

• Lab features and flow cytometry correlates with clinicalphenotypes • I think I have the mast cell • HαT and implications in clinical practice • Early phases and pre-phases of mast cell neoplasms • Classification of pre-SM conditions and developmentof prevention strategies

Chaired by Iván Álvarez-Twose & Karin Hartmann Alberto Orfao Clive Grattan Jonathan Lyons Olivier Hermine Peter Valent

13:45–15:00

SESSION 5: Diagnostic challenges in mastocytosis

• Lab features and flow cytometry correlates with clinicalphenotypes • I think I have the mast cell • HαT and implications in clinical practice • Early phases and pre-phases of mast cell neoplasms • Classification of pre-SM conditions and developmentof prevention strategies

Chaired by Iván Álvarez-Twose & Karin Hartmann Alberto Orfao Clive Grattan Jonathan Lyons Olivier Hermine Peter Valent

15:00–15:25

Afternoon coffee break

15:00–15:25

Afternoon coffee break

15:00–15:25

Afternoon coffee break

15:25–16:40

SESSION 6: Anaphylaxis and mast cell activation syndrome

• Why we have mast cells: The venom interception theory • How to manage false-positive MCAS and its mimickers • Diagnosis and management of MCAS • Immunotherapy in mastocytosis • Long- or short-term Hymenoptera venom immunotherapyin mastocytosis?

Chaired by Jens Peter Panse & Hanneke Oude Elberink Stephen Galli Theo Gulen Cem Akin Marek Niedoszytko Patrizia Bonadonna

15:25–16:40

SESSION 6: Anaphylaxis and mast cell activation syndrome

• Why we have mast cells: The venom interception theory • How to manage false-positive MCAS and its mimickers • Diagnosis and management of MCAS • Immunotherapy in mastocytosis • Long- or short-term Hymenoptera venom immunotherapyin mastocytosis?

Chaired by Jens Peter Panse & Hanneke Oude Elberink Stephen Galli Theo Gulen Cem Akin Marek Niedoszytko Patrizia Bonadonna

15:25–16:40

SESSION 6: Anaphylaxis and mast cell activation syndrome

• Why we have mast cells: The venom interception theory • How to manage false-positive MCAS and its mimickers • Diagnosis and management of MCAS • Immunotherapy in mastocytosis • Long- or short-term Hymenoptera venom immunotherapyin mastocytosis?

Chaired by Jens Peter Panse & Hanneke Oude Elberink Stephen Galli Theo Gulen Cem Akin Marek Niedoszytko Patrizia Bonadonna

16:40–17:10

Afternoon coffee break

16:40–17:10

Afternoon coffee break

16:40–17:10

Afternoon coffee break

17:10–18:25

SESSION 7: Translational and real-world research in mastocytosis

• Which biomarkers are useful in mast cell activation? • Detection of KIT variants in blood and skin of patients with mastocytosis • Tryptase: From bench to clinical use in applied haematology • Biology of tryptase and application in practice • Tryptase as a screening parameter in paediatric mastocytosis

Chaired by Sigurd Broesby-Olsen & Marek Niedoszytko Gunnar Nilsson Sigurd Broesby-Olsen Wolfgang R. Sperr Lawrence B. Schwartz Knut Brockow

17:10–18:25

SESSION 7: Translational and real-world research in mastocytosis

• Which biomarkers are useful in mast cell activation? • Detection of KIT variants in blood and skin of patients with mastocytosis • Tryptase: From bench to clinical use in applied haematology • Biology of tryptase and application in practice • Tryptase as a screening parameter in paediatric mastocytosis

Chaired by Sigurd Broesby-Olsen & Marek Niedoszytko Gunnar Nilsson Sigurd Broesby-Olsen Wolfgang R. Sperr Lawrence B. Schwartz Knut Brockow

17:10–18:25

SESSION 7: Translational and real-world research in mastocytosis

• Which biomarkers are useful in mast cell activation? • Detection of KIT variants in blood and skin of patients with mastocytosis • Tryptase: From bench to clinical use in applied haematology • Biology of tryptase and application in practice • Tryptase as a screening parameter in paediatric mastocytosis

Chaired by Sigurd Broesby-Olsen & Marek Niedoszytko Gunnar Nilsson Sigurd Broesby-Olsen Wolfgang R. Sperr Lawrence B. Schwartz Knut Brockow

18:25–18:30

Summary of Day 2 and announcements

18:25–18:30

Summary of Day 2 and announcements

18:25–18:30

Summary of Day 2 and announcements

19:00–22:00

19:00–22:00

19:00–22:00

Networking dinner

Networking dinner

Networking dinner

Join colleagues, faculty, and peers for a formal seated dinner in a distinguished setting, offering the perfect opportunity to unwind after a full day of engaging scientific discussions.

Enjoy an elegant evening of fine dining and conversation in the company of leading experts from across the field.

Dinner at Merchant Taylors’ Hall, City of London

Kindly register for this dinner by 31 August via the following link: www.surveymonkey.com/r/3YZDHTL

Join colleagues, faculty, and peers for a formal seated dinner in a distinguished setting, offering the perfect opportunity to unwind after a full day of engaging scientific discussions.

Enjoy an elegant evening of fine dining and conversation in the company of leading experts from across the field.

Dinner at Merchant Taylors’ Hall, City of London

Kindly register for this dinner by 31 August via the following link: www.surveymonkey.com/r/3YZDHTL

Join colleagues, faculty, and peers for a formal seated dinner in a distinguished setting, offering the perfect opportunity to unwind after a full day of engaging scientific discussions.

Enjoy an elegant evening of fine dining and conversation in the company of leading experts from across the field.

Dinner at Merchant Taylors’ Hall, City of London

Kindly register for this dinner by 31 August via the following link: www.surveymonkey.com/r/3YZDHTL

Day 3, Saturday 20

Day 3, Saturday 20

Day 3, Saturday 20

September 2025

September 2025

September 2025

08:00

Welcome and registration

08:00

Welcome and registration

08:00

Welcome and registration

08:30–09:30

SESSION 8: Prognostication and efficacy of novel TKIs in SM

• Development of MARS-R • Efficacy of recently approved and novel TKIs in SM clinicalpractice • Real-world data of avapritinib-treated patients with ISM • Diagnosis, prognostication and therapy of WDSM

Chaired by Tracy George & Juliana Schwaab Johannes Lübke Juliana Schwaab Frank Siebenhaar Iván Álvarez-Twose

08:30–09:30

SESSION 8: Prognostication and efficacy of novel TKIs in SM

• Development of MARS-R • Efficacy of recently approved and novel TKIs in SM clinicalpractice • Real-world data of avapritinib-treated patients with ISM • Diagnosis, prognostication and therapy of WDSM

Chaired by Tracy George & Juliana Schwaab Johannes Lübke Juliana Schwaab Frank Siebenhaar Iván Álvarez-Twose

08:30–09:30

SESSION 8: Prognostication and efficacy of novel TKIs in SM

• Development of MARS-R • Efficacy of recently approved and novel TKIs in SM clinicalpractice • Real-world data of avapritinib-treated patients with ISM • Diagnosis, prognostication and therapy of WDSM

Chaired by Tracy George & Juliana Schwaab Johannes Lübke Juliana Schwaab Frank Siebenhaar Iván Álvarez-Twose

09:30–10:00

Morning coffee break

09:30–10:00

Morning coffee break

09:30–10:00

Morning coffee break

10:00–12:00

SESSION 9: Invited presentations and late-breaking abstracts

Chaired by Deepti Radia & Jason Gotlib

10:00–12:00

SESSION 9: Invited presentations and late-breaking abstracts

Chaired by Deepti Radia & Jason Gotlib

10:00–12:00

SESSION 9: Invited presentations and late-breaking abstracts

Chaired by Deepti Radia & Jason Gotlib

12:00–13:00

Lunch break and poster sessions

12:00–13:00

Lunch break and poster sessions

12:00–13:00

Lunch break and poster sessions

13:00–14:15

SESSION 10: Updates in management of advanced and non-advanced systemic mastocytosis – looking forwards

• Non-advanced SM landscape: TKIs • Non-advanced SM landscape: Non-TKIs • Mutational landscape changing the paradigm for treatment • Advanced SM landscape and complete remission and cure: The new goal in patients with advanced SM: Status 2025 • Role of allogeneic BMT

Chaired by Frank Siebenhaar & Peter Valent Cem Akin Vito Sabato Andreas Reiter Jason Gotlib Deepti Radia

13:00–14:15

SESSION 10: Updates in management of advanced and non-advanced systemic mastocytosis – looking forwards

• Non-advanced SM landscape: TKIs • Non-advanced SM landscape: Non-TKIs • Mutational landscape changing the paradigm for treatment • Advanced SM landscape and complete remission and cure: The new goal in patients with advanced SM: Status 2025 • Role of allogeneic BMT

Chaired by Frank Siebenhaar & Peter Valent Cem Akin Vito Sabato Andreas Reiter Jason Gotlib Deepti Radia

13:00–14:15

SESSION 10: Updates in management of advanced and non-advanced systemic mastocytosis – looking forwards

• Non-advanced SM landscape: TKIs • Non-advanced SM landscape: Non-TKIs • Mutational landscape changing the paradigm for treatment • Advanced SM landscape and complete remission and cure: The new goal in patients with advanced SM: Status 2025 • Role of allogeneic BMT

Chaired by Frank Siebenhaar & Peter Valent Cem Akin Vito Sabato Andreas Reiter Jason Gotlib Deepti Radia

14:15–14:30

Summary of Day 3 and closing remarks

Peter Valent Massimo Triggiani Deepti Radia Clive Grattan

14:15–14:30

Summary of Day 3 and closing remarks

Peter Valent Massimo Triggiani Deepti Radia Clive Grattan

14:15–14:30

Summary of Day 3 and closing remarks

Peter Valent Massimo Triggiani Deepti Radia Clive Grattan